Regulation of mitotic spindle assembly

Across TCGA patient cohorts, RNA activity of the Regulation of mitotic spindle assembly pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STMN1_S16, THBS2, and WDR4_S391, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitotic spindle assembly activity versus STMN1_S16 in GBM (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	STMN1_S16 →	+0.345	+0.046	<.001	<.001	3	6
CCRCC	THBS2 →	+0.832	+0.026	.002	.004	3	5
GBM	WDR4_S391 →	-0.767	-0.053	<.001	<.001	3	5
BRCA	RPRD2 →	+0.220	+0.037	<.001	<.001	3	5
UCEC	PARP1 →	+0.349	+0.056	<.001	.002	3	5
LUAD	STMN1_S63 →	+0.473	+0.028	.004	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901673 vs STMN1_S16 — GBM

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