Regulation of mitotic spindle assembly

Across TCGA patient cohorts, RNA activity of the Regulation of mitotic spindle assembly pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAP1GAP, PCDHA11, and FKBP3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitotic spindle assembly activity versus RAP1GAP in OV (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RAP1GAP →	-0.882	-0.138	<.001	<.001	3	3
LUAD	PCDHA11 →	-0.712	-0.136	<.001	<.001	3	3
PDAC	FKBP3 →	+0.396	+0.132	<.001	<.001	3	3
UCEC	ASNSD1 →	-0.290	-0.121	.009	.007	3	3
GBM	HSD11B1-AS1 →	+0.605	+0.124	.006	<.001	3	3
GBM	RPL32P26 →	+0.459	+0.088	.008	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901673 vs RAP1GAP — OV

Explore this scatter interactively →