Regulation of mitotic spindle assembly

Across TCGA cell cohorts, RNA activity of the Regulation of mitotic spindle assembly pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CIAO1, ANKS6, and ANKS3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CIAO1 grouped by Regulation of mitotic spindle assembly-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CIAO1 →	+1.000	+0.182	.002	.007	3	5
KIDNEY	ANKS6 →	+0.998	+0.193	.004	.005	3	4
OESOPHAGUS	ANKS3 →	+0.919	+0.149	.005	.007	3	4
OESOPHAGUS	ZDHHC24 →	+1.030	+0.173	.001	.002	3	4
OESOPHAGUS	SEZ6L2 →	+2.300	+0.210	<.001	<.001	3	4
OESOPHAGUS	MAFK →	+1.778	+0.199	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CIAO1 by Regulation of mitotic spindle assembly activity — OESOPHAGUS

Explore this box plot interactively →