Regulation of mitotic spindle assembly

Across TCGA cell cohorts, RNA activity of the Regulation of mitotic spindle assembly pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are S100A3, MGAT4A, and ZNF808, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitotic spindle assembly activity versus S100A3 in SKIN (Pearson r = -0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	S100A3 →	-2.088	-0.210	<.001	<.001	3	5
SKIN	MGAT4A →	+0.737	+0.155	.003	.005	3	5
BLOOD_Myeloma	ZNF808 →	+1.367	+0.240	.006	.007	3	5
LIVER	TMEM171 →	-2.652	-0.335	.003	.006	3	4
LIVER	FPGT →	-0.822	-0.308	.002	<.001	3	4
LUNG_SCLC	ERLIN1 →	-0.866	-0.267	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901673 vs S100A3 — SKIN

Explore this scatter interactively →