Quinone metabolic process

Across TCGA patient cohorts, RNA activity of the Quinone metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AKR1C2, TXNRD1, and GSR, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Quinone metabolic process activity versus AKR1C2 in LSCC (Pearson r = 0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	AKR1C2 →	+1.633	+0.064	<.001	<.001	3	7
LSCC	TXNRD1 →	+0.841	+0.046	<.001	<.001	3	6
LSCC	GSR →	+0.410	+0.045	<.001	<.001	3	6
UCEC	AKR1C3 →	+1.566	+0.060	<.001	<.001	3	6
LSCC	GCSH →	+0.396	+0.044	<.001	<.001	3	6
LSCC	PIR →	+0.715	+0.053	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901661 vs AKR1C2 — LSCC

Explore this scatter interactively →