Quinone metabolic process

Across TCGA patient cohorts, RNA activity of the Quinone metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKR1C2, AKR1C3, and AKR1C1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Quinone metabolic process activity versus AKR1C2 in UCEC (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AKR1C2 →	+2.119	+0.200	.002	<.001	3	7
OV	AKR1C3 →	+1.177	+0.223	.002	.003	3	7
LSCC	AKR1C1 →	+1.662	+0.178	.006	.001	3	6
LSCC	CYP4F11 →	+1.884	+0.172	.001	<.001	3	5
UCEC	EPHX1 →	+0.921	+0.160	<.001	.006	3	4
UCEC	ERMP1 →	+0.703	+0.161	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901661 vs AKR1C2 — UCEC

Explore this scatter interactively →