Quinone metabolic process

Across TCGA cell cohorts, RNA activity of the Quinone metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDUFAF4, COQ3, and TRAP1, each associated with the pathway in up to 19 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Quinone metabolic process activity versus NDUFAF4 in LARGE_INTESTINE (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NDUFAF4 →	+0.958	+0.096	<.001	<.001	3	19
BLOOD_Myeloma	COQ3 →	+1.397	+0.094	<.001	<.001	3	17
BONE	TRAP1 →	+1.256	+0.062	<.001	.002	3	17
BREAST	RTN4IP1 →	+1.029	+0.091	.008	<.001	3	16
OVARY	C1QBP →	+1.424	+0.119	<.001	<.001	3	15
CNS	SLC25A19 →	+0.959	+0.097	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901661 vs NDUFAF4 — LARGE_INTESTINE

Explore this scatter interactively →