Quinone metabolic process

Across TCGA cell cohorts, RNA activity of the Quinone metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FDXR, NQO1, and CDCA7, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Quinone metabolic process activity versus FDXR in OVARY (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	FDXR →	+1.881	+1.246	<.001	<.001	3	11
CNS	NQO1 →	+2.390	+1.101	<.001	<.001	3	7
LUNG_NSCLC_LUSC	CDCA7 →	-1.284	-1.126	.002	<.001	3	5
OVARY	GPRC5C →	+3.841	+1.366	.007	<.001	3	5
CNS	AKR1C2 →	+2.593	+0.732	.002	.008	3	5
LUNG_SCLC	RBM14 →	-0.389	-1.070	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901661 vs FDXR — OVARY

Explore this scatter interactively →