Glycosyl compound catabolic process

Across TCGA patient cohorts, RNA activity of the Glycosyl compound catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LILRB3, LILRA6, and CYTH4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycosyl compound catabolic process activity versus LILRB3 in GBM (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LILRB3 →	+1.053	+0.203	<.001	<.001	3	7
GBM	LILRA6 →	+0.743	+0.128	<.001	<.001	3	7
UCEC	CYTH4 →	+0.908	+0.223	<.001	<.001	3	7
BRCA	IL21R →	+0.919	+0.274	<.001	<.001	3	7
BRCA	PLEK →	+0.918	+0.258	<.001	<.001	3	7
GBM	CD274 →	+1.140	+0.174	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901658 vs LILRB3 — GBM

Explore this scatter interactively →