Glycosyl compound catabolic process

Across TCGA cell cohorts, RNA activity of the Glycosyl compound catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DSTN, PARM1, and USP51, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DSTN grouped by Glycosyl compound catabolic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DSTN →	+0.639	+1.147	.005	.007	2	7
BONE	PARM1 →	-2.946	-0.694	.002	<.001	3	4
CNS	USP51 →	+0.385	+1.001	<.001	.002	3	4
LUNG_NSCLC_LUAD	HM13 →	+0.805	+0.643	<.001	.001	3	4
BONE	CTSD →	+1.984	+0.809	.009	.005	3	4
BONE	ZFYVE1 →	+0.976	+0.663	.003	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DSTN by Glycosyl compound catabolic process activity — LARGE_INTESTINE

Explore this box plot interactively →