Glycosyl compound catabolic process

Across TCGA cell cohorts, RNA activity of the Glycosyl compound catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ETV3, CSNK1G2, and FAM221A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycosyl compound catabolic process activity versus ETV3 in PANCREAS (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ETV3 →	+0.550	+1.216	.001	.001	3	6
BLOOD_Leukemia	CSNK1G2 →	+0.609	+0.460	<.001	.005	3	5
PANCREAS	FAM221A →	+1.921	+1.085	<.001	<.001	3	4
PANCREAS	FAM117B →	+1.016	+1.133	<.001	.001	3	4
PANCREAS	DUSP6 →	+1.918	+1.361	.001	<.001	3	4
PANCREAS	SNX27 →	+0.540	+0.960	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901658 vs ETV3 — PANCREAS

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