Glycosyl compound metabolic process

pathway activity — cross-omics
GO:1901657Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Glycosyl compound metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FGD2, MILR1, and CYTH4, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
HNSCFGD2 →+0.531+0.122<.001<.00138
COADMILR1 →+0.631+0.200.002<.00138
GBMCYTH4 →+0.746+0.113.001.00437
OVJAK3 →+0.940+0.329.001<.00137
BRCAGMFG →+0.581+0.124<.001<.00137
BRCAPTPN7 →+0.813+0.200<.001<.00137
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

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