Glycoside transport

Across TCGA patient cohorts, RNA activity of the Glycoside transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AKR1B10, SPR_S103, and ABCC3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycoside transport activity versus AKR1B10 in LSCC (Pearson r = 0.54).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	AKR1B10 →	+1.949	+0.113	<.001	<.001	3	6
PDAC	SPR_S103 →	+0.565	+0.090	<.001	<.001	3	6
GBM	ABCC3 →	+0.908	+0.177	<.001	<.001	3	6
HNSC	WASL →	+0.245	+0.081	<.001	.001	3	5
BRCA	FAM110C_S241 →	+0.831	+0.077	.001	<.001	3	5
GBM	HTATIP2 →	+0.547	+0.119	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901656 vs AKR1B10 — LSCC

Explore this scatter interactively →