Glycoside transport

Across TCGA patient cohorts, RNA activity of the Glycoside transport pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGHJ1, FCRL5, and IGHJ5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycoside transport activity versus IGHJ1 in UCEC (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGHJ1 →	-1.712	-0.467	.002	.007	2	5
LUAD	FCRL5 →	-0.996	-0.718	<.001	<.001	3	4
LUAD	IGHJ5 →	-1.029	-0.499	<.001	.006	3	4
BRCA	SYPL1 →	+0.581	+0.605	.001	.003	3	4
LUAD	VTA1 →	+0.393	+0.571	<.001	.006	3	4
LUAD	TMEM128 →	+0.377	+0.802	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901656 vs IGHJ1 — UCEC

Explore this scatter interactively →