Glycoside transport

Across TCGA cell cohorts, RNA activity of the Glycoside transport pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GBP1, QTRT2, and PSMB8, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GBP1 grouped by Glycoside transport-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	GBP1 →	+2.540	+1.557	<.001	<.001	3	5
PANCREAS	QTRT2 →	-0.725	-1.191	.002	.008	3	4
STOMACH	PSMB8 →	+3.025	+1.404	.004	<.001	3	4
LIVER	HHEX →	-1.788	-1.896	.002	<.001	3	4
LIVER	CCDC71L →	+1.700	+1.712	.003	.002	3	4
URINARY_TRACT	COIL →	-0.802	-1.484	.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GBP1 by Glycoside transport activity — STOMACH

Explore this box plot interactively →