Cellular response to ketone

Across TCGA patient cohorts, RNA activity of the Cellular response to ketone pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC1_S368, SERBP1, and TBC1D2B, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to ketone activity versus RFC1_S368 in GBM (Pearson r = -0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RFC1_S368 →	-0.744	-0.031	<.001	.001	3	8
GBM	SERBP1 →	-0.207	-0.030	.006	.008	2	9
OV	TBC1D2B →	+0.301	+0.027	<.001	<.001	3	8
GBM	HGF →	+0.877	+0.037	<.001	<.001	3	8
GBM	LCP1 →	+0.788	+0.033	<.001	<.001	3	8
LSCC	PIP4K2A →	+0.417	+0.041	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901655 vs RFC1_S368 — GBM

Explore this scatter interactively →