Cellular response to ketone

Across TCGA cell cohorts, RNA activity of the Cellular response to ketone pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF431, GOT2, and PTPMT1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to ketone activity versus ZNF431 in BONE (Pearson r = -0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ZNF431 →	-2.107	-0.419	.004	<.001	3	5
URINARY_TRACT	GOT2 →	-0.765	-0.295	.005	.007	3	5
CNS	PTPMT1 →	-0.748	-0.293	<.001	<.001	3	4
URINARY_TRACT	NME2 →	-0.958	-0.292	.002	.004	3	4
CNS	DHRS11 →	-0.905	-0.243	.001	.003	3	4
LUNG_NSCLC_LUAD	SRSF4 →	-0.513	-0.175	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901655 vs ZNF431 — BONE

Explore this scatter interactively →