Response to ketone

Across TCGA patient cohorts, RNA activity of the Response to ketone pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GEM_S23, L3HYPDH, and PPM1F, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to ketone activity versus GEM_S23 in LSCC (Pearson r = 0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GEM_S23 →	+1.179	+0.052	<.001	<.001	3	9
COAD	L3HYPDH →	+0.529	+0.024	<.001	<.001	3	9
UCEC	PPM1F →	+0.278	+0.040	<.001	<.001	3	9
LSCC	RPL10A →	-0.134	-0.025	<.001	<.001	3	8
OV	SERBP1 →	-0.243	-0.030	.009	.002	2	9
GBM	DAB2 →	+0.746	+0.038	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901654 vs GEM_S23 — LSCC

Explore this scatter interactively →