Response to ketone

Across TCGA patient cohorts, RNA activity of the Response to ketone pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NECAP1P1, KCTD9P4, and YBX1P3, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to ketone activity versus NECAP1P1 in BRCA (Pearson r = 0.02).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NECAP1P1 →	+0.220	+0.282	.004	.005	3	2
BRCA	KCTD9P4 →	+0.309	+0.336	<.001	.001	3	2
BRCA	YBX1P3 →	+0.146	+0.331	<.001	<.001	3	2
OV	PLCH1 →	-1.289	-0.168	.002	<.001	3	2
OV	SNRPCP17 →	+1.850	+0.184	.004	.007	3	2
OV	VMP1 →	+1.367	+0.202	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901654 vs NECAP1P1 — BRCA

Explore this scatter interactively →