Response to ketone

Across TCGA cell cohorts, RNA activity of the Response to ketone pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are INO80B, NAAA, and HPSE, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, INO80B grouped by Response to ketone-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	INO80B →	+0.637	+0.160	.001	<.001	3	5
LUNG_SCLC	NAAA →	+2.016	+0.120	.006	.008	2	5
STOMACH	HPSE →	-2.121	-0.197	<.001	.001	3	4
SOFT_TISSUE	SAMD12 →	-1.336	-0.181	.001	<.001	3	4
OESOPHAGUS	TTLL4 →	+0.773	+0.159	.001	.002	3	4
OESOPHAGUS	SF3B6 →	+0.936	+0.158	.006	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

INO80B by Response to ketone activity — LARGE_INTESTINE

Explore this box plot interactively →