Response to ketone

Across TCGA cell cohorts, RNA activity of the Response to ketone pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NIPAL1, SIAE, and LRP3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to ketone activity versus NIPAL1 in OESOPHAGUS (Pearson r = -0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	NIPAL1 →	-1.097	-0.167	<.001	<.001	3	5
STOMACH	SIAE →	+1.470	+0.186	.002	.004	3	4
SKIN	LRP3 →	+1.729	+0.124	<.001	.005	2	5
LUNG_NSCLC_LUSC	ALDH1A3 →	-4.082	-0.273	.003	<.001	3	4
SKIN	INPP5B →	+0.647	+0.131	.007	.003	3	4
BONE	APOO →	+0.810	+0.210	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901654 vs NIPAL1 — OESOPHAGUS

Explore this scatter interactively →