Nucleoside transmembrane transport

Across TCGA patient cohorts, RNA activity of the Nucleoside transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PXDN, S100A2, and SH3GL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleoside transmembrane transport activity versus PXDN in PDAC (Pearson r = -0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PXDN →	-0.306	-0.051	<.001	<.001	3	4
LSCC	S100A2 →	-1.879	-0.082	<.001	<.001	2	4
COAD	SH3GL1 →	-0.160	-0.043	.008	.004	2	4
LSCC	EPPK1_T2572 →	-0.576	-0.115	.004	<.001	3	3
LSCC	KRT15_S148 →	-1.295	-0.057	.005	.001	3	3
OV	ABRAXAS1_S406 →	-1.956	-0.100	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901642 vs PXDN — PDAC

Explore this scatter interactively →