Nucleoside transmembrane transport

Across TCGA patient cohorts, RNA activity of the Nucleoside transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are APOC1, NFASC, and PIM2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleoside transmembrane transport activity versus APOC1 in CCRCC (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	APOC1 →	+0.760	+0.546	.001	.001	3	5
BRCA	NFASC →	-0.751	-0.600	.005	.005	3	4
LSCC	PIM2 →	+0.642	+0.393	.008	.007	3	3
LSCC	DOCK8 →	+0.685	+0.429	<.001	<.001	3	3
UCEC	GBP1 →	+1.256	+0.313	.006	.001	3	3
LSCC	IRF1 →	+0.787	+0.509	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901642 vs APOC1 — CCRCC

Explore this scatter interactively →