Nucleoside transmembrane transport

Across TCGA cell cohorts, RNA activity of the Nucleoside transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNRK, NBPF20, and KRTCAP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SNRK grouped by Nucleoside transmembrane transport-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SNRK →	-1.237	-1.120	.003	.006	3	4
STOMACH	NBPF20 →	-0.600	-1.015	.001	.006	3	4
LUNG_NSCLC_LUAD	KRTCAP2 →	+0.453	+0.674	.008	.009	3	4
PANCREAS	IP6K2 →	-1.114	-1.751	<.001	<.001	3	4
SOFT_TISSUE	ATP5PB →	+0.515	+0.813	<.001	.005	3	3
SOFT_TISSUE	CBX4 →	-1.236	-0.794	.002	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SNRK by Nucleoside transmembrane transport activity — OVARY

Explore this box plot interactively →