Regulation of synaptic vesicle membrane organization

Across TCGA cell cohorts, RNA activity of the Regulation of synaptic vesicle membrane organization pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPAG9, IKBKG, and ZNF793, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SPAG9 grouped by Regulation of synaptic vesicle membrane organization-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SPAG9 →	-0.765	-1.017	<.001	.004	3	4
LUNG_NSCLC_LUAD	IKBKG →	-0.563	-1.111	.008	<.001	3	4
SOFT_TISSUE	ZNF793 →	+1.861	+1.502	<.001	<.001	3	4
LARGE_INTESTINE	STK3 →	-0.833	-1.119	.004	.002	3	3
LARGE_INTESTINE	NUFIP2 →	-0.866	-1.063	.007	.008	3	3
LARGE_INTESTINE	RTN4 →	-0.529	-0.812	.002	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SPAG9 by Regulation of synaptic vesicle membrane organization activity — LARGE_INTESTINE

Explore this box plot interactively →