Regulation of lymphocyte chemotaxis

Across TCGA cell cohorts, RNA activity of the Regulation of lymphocyte chemotaxis pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WNK1, ADAM17, and PTPRG, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WNK1 grouped by Regulation of lymphocyte chemotaxis-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	WNK1 →	-0.538	-1.405	.004	.002	3	5
BONE	ADAM17 →	-0.343	-1.834	.001	<.001	2	6
BLOOD_Myeloma	PTPRG →	+0.546	+1.364	<.001	.004	3	5
KIDNEY	CCL3 →	-0.188	-1.016	.008	.005	3	4
OVARY	CCL7 →	-0.221	-1.182	<.001	<.001	3	4
BREAST	NXF5 →	+0.185	+0.784	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WNK1 by Regulation of lymphocyte chemotaxis activity — LIVER

Explore this box plot interactively →