Regulation of lymphocyte chemotaxis

Across TCGA cell cohorts, RNA activity of the Regulation of lymphocyte chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are E2F1, PRPF8, and SLC2A3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lymphocyte chemotaxis activity versus E2F1 in BREAST (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	E2F1 →	+0.775	+0.877	.001	.002	3	4
BREAST	PRPF8 →	+0.698	+0.898	<.001	.002	3	4
STOMACH	SLC2A3 →	-3.325	-0.918	.003	.002	3	4
PANCREAS	CRYGS →	+0.898	+0.820	.004	.004	3	4
CNS	CEP68 →	-0.734	-1.135	<.001	.004	3	3
BLOOD_Leukemia	SMG6 →	+0.975	+0.612	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901623 vs E2F1 — BREAST

Explore this scatter interactively →