Positive regulation of vesicle transport along microtubule

Across TCGA cell cohorts, RNA activity of the Positive regulation of vesicle transport along microtubule pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DENND4A, SOX4, and REXO5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DENND4A grouped by Positive regulation of vesicle transport along microtubule-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	DENND4A →	+0.882	+1.287	.009	.007	3	5
OVARY	SOX4 →	-1.408	-0.971	.004	.002	3	4
OVARY	REXO5 →	+0.758	+0.912	.003	.005	3	4
BREAST	CDKN2D →	+1.360	+1.434	<.001	<.001	3	4
BREAST	SMIM10 →	+1.060	+0.918	.005	.001	3	4
LUNG_NSCLC_LUSC	PTX3 →	+4.834	+1.654	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DENND4A by Positive regulation of vesicle transport along microtubule activity — OESOPHAGUS

Explore this box plot interactively →