Positive regulation of vesicle transport along microtubule

Across TCGA cell cohorts, RNA activity of the Positive regulation of vesicle transport along microtubule pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C20orf173, ZMIZ2, and POLR1H, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C20orf173 grouped by Positive regulation of vesicle transport along microtubule-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	C20orf173 →	+0.190	+0.203	<.001	<.001	3	4
BONE	ZMIZ2 →	-0.278	-0.122	<.001	<.001	3	4
OESOPHAGUS	POLR1H →	-0.278	-0.153	.004	.005	3	4
LUNG_NSCLC_LUSC	CBLN2 →	-0.274	-0.183	.006	<.001	3	3
LUNG_NSCLC_LUSC	BCL6B →	-0.160	-0.145	.003	<.001	3	3
LARGE_INTESTINE	TYMS →	+0.270	+0.088	.008	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C20orf173 by Positive regulation of vesicle transport along microtubule activity — LUNG_SCLC

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