Fatty acid derivative biosynthetic process

Across TCGA patient cohorts, RNA activity of the Fatty acid derivative biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the ESCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACSL5, ELOVL6, and CCRL2, each associated with the pathway in up to 21 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fatty acid derivative biosynthetic process activity versus ACSL5 in ESCA (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	ACSL5 →	+1.716	+0.041	<.001	<.001	3	21
CHOL	ELOVL6 →	+1.528	+0.051	.001	.008	1	21
TGCT	CCRL2 →	+0.927	+0.033	<.001	<.001	3	18
KICH	SLC27A2 →	+1.409	+0.029	<.001	<.001	3	16
ESCA	MYO1A →	+1.553	+0.040	<.001	<.001	3	16
UVM	ZMYND15 →	+0.867	+0.020	<.001	.003	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901570 vs ACSL5 — ESCA

Explore this scatter interactively →