Fatty acid derivative biosynthetic process

Across TCGA patient cohorts, RNA activity of the Fatty acid derivative biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNTN3, CCDC77, and TMEM38B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fatty acid derivative biosynthetic process activity versus CNTN3 in CCRCC (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CNTN3 →	+0.998	+0.194	<.001	<.001	3	5
UCEC	CCDC77 →	-0.644	-0.280	<.001	.001	3	5
LSCC	TMEM38B →	-0.673	-0.188	.001	<.001	3	5
UCEC	VRK1 →	-0.677	-0.286	<.001	<.001	3	4
LSCC	CEP192 →	-0.444	-0.159	<.001	<.001	3	4
LUAD	RPL24 →	-0.281	-0.153	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901570 vs CNTN3 — CCRCC

Explore this scatter interactively →