Fatty acid derivative biosynthetic process

Across TCGA cell cohorts, RNA activity of the Fatty acid derivative biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLAG1, CCN1, and ASH2L, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLAG1 grouped by Fatty acid derivative biosynthetic process-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	PLAG1 →	-1.257	-2.135	.008	<.001	3	6
SKIN	CCN1 →	-2.065	-0.874	.001	.005	3	5
SKIN	ASH2L →	+0.510	+1.050	.002	<.001	3	4
OVARY	DAAM2 →	+0.994	+1.049	.008	.004	3	4
PANCREAS	BBX →	-0.734	-1.232	<.001	.003	3	3
BLOOD_Leukemia	LOXL3 →	-1.593	-1.238	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLAG1 by Fatty acid derivative biosynthetic process activity — BLOOD_Myeloma

Explore this box plot interactively →