Fatty acid derivative biosynthetic process

Across TCGA cell cohorts, RNA activity of the Fatty acid derivative biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SRSF11, HDGFL3, and USP48, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fatty acid derivative biosynthetic process activity versus SRSF11 in SKIN (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SRSF11 →	+0.610	+0.199	.003	<.001	3	5
LARGE_INTESTINE	HDGFL3 →	-3.241	-0.330	<.001	<.001	3	4
LUNG_NSCLC_LUSC	USP48 →	+0.640	+0.141	.002	.006	3	4
STOMACH	WDR43 →	-0.836	-0.291	.003	<.001	3	4
STOMACH	COPS2 →	-0.528	-0.207	<.001	.004	3	4
STOMACH	NOP16 →	-0.679	-0.207	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901570 vs SRSF11 — SKIN

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