Fatty acid derivative metabolic process

Across TCGA patient cohorts, RNA activity of the Fatty acid derivative metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPATA5, HABP2, and LIN9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fatty acid derivative metabolic process activity versus SPATA5 in BRCA (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SPATA5 →	-0.346	-0.182	.007	.004	3	5
CCRCC	HABP2 →	+1.281	+0.139	.004	.002	3	5
LSCC	LIN9 →	-0.678	-0.175	<.001	.003	3	5
UCEC	SMC3 →	-0.612	-0.271	<.001	<.001	3	5
UCEC	BRCA1 →	-0.690	-0.266	.001	.001	3	5
LSCC	TMEM163 →	+0.771	+0.199	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901568 vs SPATA5 — BRCA

Explore this scatter interactively →