Fatty acid derivative metabolic process

Across TCGA cell cohorts, RNA activity of the Fatty acid derivative metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FRK, NHP2, and PGAM1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fatty acid derivative metabolic process activity versus FRK in LUNG_NSCLC_LUSC (Pearson r = 0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	FRK →	+1.512	+0.224	<.001	<.001	3	6
LUNG_NSCLC_LUAD	NHP2 →	-0.444	-0.199	.005	.003	2	6
LUNG_NSCLC_LUAD	PGAM1 →	-0.518	-0.126	.002	.006	2	6
LUNG_SCLC	PTPN6 →	+1.934	+0.180	.002	.005	3	5
LUNG_SCLC	AOPEP →	+1.396	+0.217	.002	.003	2	6
LUNG_SCLC	AKR7L →	+1.251	+0.264	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901568 vs FRK — LUNG_NSCLC_LUSC

Explore this scatter interactively →