Positive regulation of endothelial cell development

Across TCGA patient cohorts, RNA activity of the Positive regulation of endothelial cell development pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TNS2, VWF, and COL4A1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of endothelial cell development activity versus TNS2 in UCEC (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TNS2 →	+0.390	+0.086	.001	.001	3	10
UCEC	VWF →	+0.449	+0.094	.001	.001	3	10
OV	COL4A1 →	+0.685	+0.070	<.001	<.001	3	10
CCRCC	PLVAP →	+0.604	+0.076	<.001	<.001	3	10
CCRCC	RASIP1 →	+0.478	+0.094	<.001	<.001	3	10
CCRCC	CD34 →	+0.647	+0.102	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901552 vs TNS2 — UCEC

Explore this scatter interactively →