Positive regulation of endothelial cell development

Across TCGA patient cohorts, RNA activity of the Positive regulation of endothelial cell development pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIB3, ATOH8, and FRAS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of endothelial cell development activity versus TRIB3 in GBM (Pearson r = -0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TRIB3 →	-0.857	-0.215	.006	.002	3	5
LSCC	ATOH8 →	+0.605	+0.203	.003	.001	3	5
HNSC	FRAS1 →	+0.945	+0.189	<.001	.001	3	5
GBM	FAM107A →	+1.004	+0.222	<.001	<.001	3	5
BRCA	ACADL →	+0.980	+0.221	<.001	<.001	3	4
PDAC	MRAP2 →	+0.974	+0.222	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901552 vs TRIB3 — GBM

Explore this scatter interactively →