Positive regulation of endothelial cell development

Across TCGA cell cohorts, RNA activity of the Positive regulation of endothelial cell development pathway is significantly associated with the total protein of multiple features, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are Beclin, eEF2, and ER-alpha, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of endothelial cell development activity versus Beclin in OVARY (Pearson r = 0.55).

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Beclin →	+0.256	+0.471	.039	.011	3	2
OVARY	eEF2 →	-1.407	-0.471	.042	.011	3	1
OVARY	ER-alpha →	+0.322	+0.471	.006	.011	3	1
OVARY	HER2 →	-0.939	-0.471	.003	.011	3	1
OVARY	PAI-1 →	+3.292	+0.471	.013	.011	3	1
OVARY	Rab25 →	+0.362	+0.471	.009	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901552 vs Beclin — OVARY

Explore this scatter interactively →