Positive regulation of hematopoietic progenitor cell differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of hematopoietic progenitor cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H19, SCN4B, and MAPK1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of hematopoietic progenitor cell differentiation activity versus H19 in GBM (Pearson r = -0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	H19 →	-1.500	-0.500	.006	.001	3	3
HNSC	SCN4B →	-0.690	-0.204	.002	<.001	3	3
GBM	MAPK1 →	-0.392	-0.654	.001	<.001	3	3
GBM	RPL3 →	-0.277	-0.449	.004	.004	3	3
BRCA	NEK3 →	-0.393	-0.410	.003	.003	3	3
BRCA	GTF2E1 →	-0.561	-0.495	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901534 vs H19 — GBM

Explore this scatter interactively →