Positive regulation of hematopoietic progenitor cell differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of hematopoietic progenitor cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLASP2, PDCD6IP, and EXOC3L4, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of hematopoietic progenitor cell differentiation activity versus CLASP2 in LARGE_INTESTINE (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CLASP2 →	+0.965	+0.293	.005	.004	3	2
LARGE_INTESTINE	PDCD6IP →	+0.734	+0.291	<.001	<.001	3	2
LARGE_INTESTINE	EXOC3L4 →	-1.400	-0.329	.004	.004	3	2
BREAST	C17orf97 →	+1.698	+0.297	<.001	.002	3	2
LARGE_INTESTINE	MOSPD1 →	+1.570	+0.235	.001	.007	3	1
LARGE_INTESTINE	ZDHHC2 →	+1.890	+0.356	.004	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901534 vs CLASP2 — LARGE_INTESTINE

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