Negative regulation of hematopoietic progenitor cell differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of hematopoietic progenitor cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOCS2, DNAJC6, and EPHB2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of hematopoietic progenitor cell differentiation activity versus SOCS2 in LUAD (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SOCS2 →	+0.660	+0.566	.002	.008	3	4
GBM	DNAJC6 →	-0.698	-0.419	.003	.003	3	3
LSCC	EPHB2 →	-0.891	-0.592	<.001	.005	3	3
LSCC	CALM3 →	-0.328	-0.700	.003	<.001	3	3
CCRCC	ZNF726 →	-0.264	-0.303	<.001	.005	3	3
LSCC	WFS1 →	-0.521	-0.635	.002	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901533 vs SOCS2 — LUAD

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