Negative regulation of hematopoietic progenitor cell differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of hematopoietic progenitor cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STT3B_S21, CAVIN2_S366, and KDM1A_S69, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of hematopoietic progenitor cell differentiation activity versus STT3B_S21 in PDAC (Pearson r = -0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	STT3B_S21 →	-0.942	-1.421	<.001	<.001	3	3
COAD	CAVIN2_S366 →	+1.268	+1.031	<.001	<.001	3	3
COAD	KDM1A_S69 →	+0.445	+0.769	<.001	<.001	3	3
OV	CEP41_S99 →	+1.015	+1.022	<.001	<.001	3	3
UCEC	MIA2_S1125 →	+1.046	+0.928	<.001	<.001	3	3
BRCA	NES_S1286 →	+1.078	+0.903	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901533 vs STT3B_S21 — PDAC

Explore this scatter interactively →