Negative regulation of hematopoietic progenitor cell differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of hematopoietic progenitor cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPDYE6, NDUFV1, and HPS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SPDYE6 grouped by Negative regulation of hematopoietic progenitor cell differentiation-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SPDYE6 →	+0.445	+0.475	.006	.007	3	4
OESOPHAGUS	NDUFV1 →	+0.826	+0.431	.006	.002	3	3
BLOOD_Leukemia	HPS1 →	-0.815	-0.245	.007	.008	3	3
STOMACH	TMPRSS13 →	+2.606	+0.384	.005	.008	3	3
STOMACH	GJC1 →	-3.170	-0.383	<.001	<.001	3	3
LUNG_NSCLC_LUAD	C12orf76 →	-0.602	-0.237	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SPDYE6 by Negative regulation of hematopoietic progenitor cell differentiation activity — SKIN

Explore this box plot interactively →