Negative regulation of hematopoietic progenitor cell differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of hematopoietic progenitor cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMSB4X, ZDBF2, and SCN4B, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of hematopoietic progenitor cell differentiation activity versus TMSB4X in BONE (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	TMSB4X →	+2.466	+0.330	.001	.004	3	13
LUNG_NSCLC_LUAD	ZDBF2 →	-0.931	-0.233	.002	<.001	3	5
BREAST	SCN4B →	-0.438	-0.218	.001	.005	3	5
SOFT_TISSUE	ANKRD24 →	+0.911	+0.339	<.001	<.001	3	5
OVARY	ARHGDIA →	+1.166	+0.196	<.001	.006	3	4
OVARY	ANTKMT →	+0.622	+0.178	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901533 vs TMSB4X — BONE

Explore this scatter interactively →