Regulation of hematopoietic progenitor cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of hematopoietic progenitor cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMSB4X, ME3, and AGR3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of hematopoietic progenitor cell differentiation activity versus TMSB4X in OVARY (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TMSB4X →	+2.658	+0.279	.006	.001	3	7
LIVER	ME3 →	+3.010	+0.265	<.001	.002	2	5
KIDNEY	AGR3 →	+0.087	+0.205	.003	.003	3	4
LUNG_NSCLC_LUSC	PPP4R4 →	-2.006	-0.345	.001	<.001	3	3
LUNG_NSCLC_LUSC	ANKK1 →	-0.720	-0.356	<.001	.007	3	3
LUNG_NSCLC_LUSC	CHD7 →	+1.366	+0.280	.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901532 vs TMSB4X — OVARY

Explore this scatter interactively →