Regulation of mitophagy

Across TCGA cell cohorts, RNA activity of the Regulation of mitophagy pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBR7, TMEM33, and CDC73, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitophagy activity versus UBR7 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	UBR7 →	+1.414	+0.154	.005	.004	3	6
LUNG_NSCLC_LUSC	TMEM33 →	+0.921	+0.358	.001	.002	3	5
PANCREAS	CDC73 →	+0.573	+0.202	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	SNX6 →	+0.804	+0.134	<.001	<.001	3	5
OVARY	B4GALT2 →	+0.817	+0.279	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	PAICS →	+1.097	+0.125	.005	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901524 vs UBR7 — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →