Icosanoid catabolic process

Across TCGA patient cohorts, RNA activity of the Icosanoid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL1RL1, DARS2, and IER2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Icosanoid catabolic process activity versus IL1RL1 in BRCA (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IL1RL1 →	+0.539	+0.111	.002	.003	3	5
COAD	DARS2 →	-0.417	-0.264	.002	<.001	3	4
OV	IER2 →	+0.830	+0.800	.001	.001	3	4
BRCA	MOB2 →	+0.521	+0.148	<.001	<.001	3	4
LSCC	MRPL44 →	-0.332	-0.194	.005	<.001	3	4
CCRCC	HDC →	+0.477	+0.201	.006	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901523 vs IL1RL1 — BRCA

Explore this scatter interactively →