Across TCGA pan-cancer cohorts, RNA activity of the Obsolete positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus pathway is associated with patient survival in 25 of 34 cancer lineages. Pathway activity is summarized from the expression of its 17 member genes.
The strongest signal is observed in brain lower grade glioma (LGG), where higher Obsolete positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LGG and SKCM, show the opposite pattern, with higher activity associated with better survival.
LGG, KIRP, and SKCM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.
Pathway-activity survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.