Regulation of endothelial tube morphogenesis

Across TCGA cell cohorts, RNA activity of the Regulation of endothelial tube morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LCN2, SLC26A10, and FOXP1, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of endothelial tube morphogenesis activity versus LCN2 in PANCREAS (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	LCN2 →	+5.195	+0.630	<.001	<.001	3	11
LUNG_NSCLC_LUAD	SLC26A10 →	-1.864	-1.156	<.001	<.001	3	11
BLOOD_Myeloma	FOXP1 →	+2.203	+1.038	<.001	.006	3	11
OESOPHAGUS	SERPINB1 →	+2.655	+1.516	.004	.001	3	10
STOMACH	CCDC150 →	-0.958	-0.917	<.001	.001	3	10
PANCREAS	ADGRF1 →	+4.202	+1.065	<.001	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901509 vs LCN2 — PANCREAS

Explore this scatter interactively →