Regulation of endothelial tube morphogenesis

Across TCGA cell cohorts, RNA activity of the Regulation of endothelial tube morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF385D, C6orf58, and NDUFS3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of endothelial tube morphogenesis activity versus ZNF385D in LUNG_NSCLC_LUAD (Pearson r = 0.97).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ZNF385D →	+0.055	+1.660	.008	.006	3	2
LUNG_NSCLC_LUAD	C6orf58 →	+0.475	+1.660	.004	.006	3	2
LUNG_NSCLC_LUAD	NDUFS3 →	+0.775	+1.749	.007	.002	3	2
LARGE_INTESTINE	DNAH7 →	+0.885	+1.845	.007	<.001	3	2
LARGE_INTESTINE	EIF3K →	+1.216	+1.935	.005	<.001	3	2
UPPER_AERODIGESTIVE_TRACT	ERFE →	-0.925	-1.807	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901509 vs ZNF385D — LUNG_NSCLC_LUAD

Explore this scatter interactively →